Additionally, when the ALT/AST ratio increased, men (aHRs: 2.22, 95% CI: 1.81, 2.71) had a higher risk of NAFLD than women (aHRs: 2.01, 95% CI: 1.70, 2.37), and this association also existed in people with high blood pressure, high blood lipids and hyperglycaemia (Table 3). This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.