Also, transdermal administration of high-molecular-weight (HMW, 1100 kDa) poly-gamma glutamate (PGA) microneedles (MNs) significantly reduced clinical dermatitis scores, epidermal thickness, and MC infiltration in mice by downregulating IgE, suggesting that gamma-PGA MNs represent an innovative, safe, and reliable therapeutic strategy for AD management [55]. The gene discussed is IGHE; the disease is Alzheimer disease.