The recent identification of the CGRP-responsive calcitonin receptor/RAMP1 complex (CTR/RAMP1), (AMY1 receptor-amylin subtype 1 receptor) in the trigeminovascular system warrants deeper consideration of the molecular identity of CGRP receptor(s) involved in the pathophysiology and potential treatment of migraine [120, 121]. The gene discussed is CALCA; the disease is migraine disorder.