However, the Cardiff group found that a model considering plasma levels of 3 components (CLU, factor I, and C5b-9) was predictive of conversion from mild cognitive impairment (MCI) to AD over a 1-year period [219], and more recently discovered that after adjusting for age and APOE4, other combinations of complement components had some value (AUC of 0.71) in predicting progress to AD [215]. The gene discussed is APOE; the disease is Alzheimer disease.