In 2013, using an unbiased integrative network-based approach, Zhang, Gaiteri and colleagues showed that immune- and microglia-specific networks including complement genes involved in phagocytosis and inflammation, and TYROBP, a regulator of TREM2 function, are significantly upregulated in human sporadic/late-onset AD and correlated with disease traits [150]. Here, TREM2 is linked to Alzheimer disease.