C5AR1 and Alzheimer disease: These microglial profiles are consistent with the different subtypes of microglia recently identified by single-cell RNA-Seq analysis in other AD models [40, 140, 141, 170] and suggests that inhibition of C5aR1 could result in preventing or slowing the induction of detrimental proinflammatory microglial subsets, perhaps by preventing the downregulation of “inhibitory-checkpoint pathways” [141], while enabling the nonphlogistic clearance of damaged synapses, apoptotic cells, or neuronal blebs.