However, nearly 10–15% of adult GIST and 85% of pediatric GIST are negative for KIT and PDGFRA mutations, as called wild-type (WT) GIST, which is a component of the Carney-Stratakis syndrome caused by the succinyl dehydrogenase (SDH)-mutations [36]. This evidence concerns the gene PDGFRA and Carney-Stratakis syndrome.