In patients with ARDS, composite parameters including serum HO-1, P/F ratio, age and sex for prediction of 3-month mortality showed a higher AUC (0.925) than AUCs of a single predictor (only HO-1; 0.783) or combination of two (HO-1 and age; 0.783) or three predictors (HO-1, age, and sex; 0.917) (Fig. 3a). The gene discussed is HMOX1; the disease is acute respiratory distress syndrome.