HMGB1 and Hypoglycemia: Absence of HMGB1 in global knockout mice is lethal within a few days of birth, with newborn knockout mice succumbing to hypoglycemia (Calogero et al. 1999), although HMGB1 can be inducibly knocked out globally in adult mice (Aneja et al. 2019), suggesting a specific role for HMGB1 in development and early metabolism.