Immunohistochemistry and special staining: CK7 cholangiocarcinoma ( +), CK19 ( +), CD34 vascular ( +), NSE nerve ( +), Ki67 (+ , 70%), CgA, Syn neuroendocrine carcinoma ( +), p53 (cholangiocarcinoma 3 + , neuroendocrine carcinoma 2 +), VG ( +) (Fig. 2). This evidence concerns the gene KRT7 and neuroendocrine carcinoma.