Immunohistochemistry and special staining: CK7 cholangiocarcinoma ( +), CK19 ( +), CD34 vascular ( +), NSE nerve ( +), Ki67 (+ , 70%), CgA, Syn neuroendocrine carcinoma ( +), p53 (cholangiocarcinoma 3 + , neuroendocrine carcinoma 2 +), VG ( +) (Fig. 2). The gene discussed is MKI67; the disease is neuroendocrine carcinoma.