Altered EGFR glycosylation could also have impacted its downregulation induced by EGF, as suggests a report showing that the knockdown of N-acetylglucosaminyl transferase V in MDA-MB-231 cells of breast carcinoma and HT1080 cells of fibrosarcoma results in impaired receptor internalization and delayed ligand-induced downregulation [94]. The gene discussed is MGAT5; the disease is fibrosarcoma.