GOLPH3 and central nervous system cancer: Consistent with the effect of knockdown GOLPH3 expression in other glioma cell lines, and with the effect on many other different types of tumor cell lines [5], we found a significant reduction in the proliferation of cells expressing shGOLPH3#1 to 57.2 ± 8.7% compared to control shLuc cells (Figure 1A), as well as to 54.2 ± 5.2% compared to WT T98G cells (Figure S1A).