CD8A and melanoma: In B16gp melanoma models (B16F10 cells that express lymphocytic choriomeningitis virus-derived gp), IR increased expression of CD70 and CD86 costimulatory molecules on DCs and increased the number of tumor-antigen specific CD8+ T cells in the TME, suggesting that IR facilitated DC maturation and cross-priming capabilities towards effector T cells [87].