CD8A and neoplasm: Overall, studies investigating the capacity of IR to produce antitumor immune responses suggest radiotherapy facilitates transfer of tumor-derived dsDNA or cGAMP to the cytosol of DCs, which then activates cGAS–STING signaling and production of type I IFNs, ultimately enhancing DC priming capabilities and subsequent CD8+ T cell-mediated antitumor activity (Figure 1).