As for neutrophils, although the specific signals regulating liver infiltration in PSC have not been investigated, VCAM-1 has been shown to specifically mediate their adhesion to endothelium in sepsis patients [53], suggesting that under inflammatory conditions the alpha-4-integrin/VCAM-1 pathway may be selectively modulated to allow neutrophil recruitment into target organs. The gene discussed is ITGA4; the disease is Sepsis.