POLE and colorectal carcinoma: In sporadic MSI-high CRC, the most common mutated genes (more than 40%) were PMS1 (76, 82.7%), BAX (48, 52.2%), KRAS (45, 48.9%), POLE (44, 47.8%), TP53 (41, 44.6%), and APC (40, 43.4%).