Our data describe first a new mechanism for the control of metabolism that is driven by VDAC1-ΔC, the form of VDAC1 that is produced in hypoxia in many cancer cells or patients as previously described [7,8,9,13] and second, a link between VDAC1, tubulin, microtubules, and primary cilium. The gene discussed is VDAC1; the disease is cancer.