PEDF may prevent BC cell EMT by regulating nuclear factor-kappa B (NF-κB) and extracellular signal regulated kinase (ERK)/Akt signalling to decrease the expression of EMT markers vimentin, Snail, fibronectin, and matrix metalloproteinases (MMPs), and increase E-cadherin expression, an important cell adhesion molecule [25,26]. Here, AKT1 is linked to breast cancer.