Nuclear translocation and activation of FoxO transcription factors induce an increased expression of key regulating factors of the muscle-specific ubiquitin-ligases, atrogin-1 (MAFbx), and Muscle RING Finger 1 (MuRF1) that are over-expressed in the elderly and are involved in the onset of sarcopenia [15]. The gene discussed is FBXO32; the disease is sarcopenia.