In this study, traditional neuropathological characteristics of AD in response to Cr supplementation were not measured due to findings showing limited hippocampal Aβ plaque deposition or NFT (associated with tau hyperphosphorylation) at the age of mice used in the present study, features which are not robust in the hippocampus until ~12 months of age [47,70]. Here, MAPT is linked to Alzheimer disease.