In further support of this possibility, melatonin is a known antiproliferative that normalizes several overactive pathways in both cancer and ADPKD, e.g., ERK, mTOR, PI3K/Akt, PKC [1,16,53,58,71,136,137,138,139,140,141,142,143]. Here, PRRT2 is linked to autosomal dominant polycystic kidney disease.