Particularly, in ventricular remodeling following a myocardial infarction, MPO was proved to increase the collagen deposition in an experimental study that used the ligation of the left anterior descending artery [110] and the MPO-deficient mice exhibited less left ventricular dilatation and attenuated impairment in systolic left ventricular functions [111,112]. This evidence concerns the gene MPO and Left ventricular dilatation.