Another report showed that the induction of NQO1 by several synthetic triterpenoids resulted in the decreased expression of the pro-inflammatory inducible nitric oxide synthase (iNOS) in Hepa1c1c7 murine hepatoma cells, an effect that was strictly Nrf2-dependent and related to the direct interaction with Keap1 thiol groups [90]. Here, NFE2L2 is linked to hepatocellular carcinoma.