NFE2L2 and Familial prostate cancer: A recent paper studying inflammation in prostate cancer and castration-resistant prostate cancer showed that antioxidant and anti-inflammatory agents such as sulforaphane and curcumin can activate Nrf-2 and induces the nuclear accumulation of p120-Nrf1 which in turn significantly inhibits NF-κB DNA-binding activity by decreasing the transactivation of androgen receptor signaling [56].