While our study is on an experimental model (the hypertensive (SHR) and diabetic (STZ-induced) rat), it draws attention of translational relevance for human diabetes associated with hypertension since these patients might not be as sensible as expected to the diuretic/natriuretic effects that have been attributed to selective adenosine A1-receptor antagonists [59]. Here, ADORA1 is linked to Hypertension.