For this purpose, we determined gene expression values by qRT-PCR for the six RAS genes (AGT, ANPEP, ATP6AP2, CPA3, CTSA and IGF2R (two probesets)) and used these to predict in vitro IC50 values obtained for Etoposide and Doxorubicin calculated with 6M approach for nine AML cell lines (see Materials and methods section). The gene discussed is ATP6AP2; the disease is acute myeloid leukemia.