For this purpose, we determined gene expression values by qRT-PCR for the six RAS genes (AGT, ANPEP, ATP6AP2, CPA3, CTSA and IGF2R (two probesets)) and used these to predict in vitro IC50 values obtained for Etoposide and Doxorubicin calculated with 6M approach for nine AML cell lines (see Materials and methods section). Here, IGF2R is linked to acute myeloid leukemia.