Adenoma of the pituitary gland producing ACTH—Cushing disease (CD) is the most common source of endogenous hypercortisolemia, which accounts for about 60–70% of all CS cases [3] whereas less common are adenomas of the suprarenal gland—a condition known as ACTH-independent CS (10–20% of all CS patients) [2]. The gene discussed is POMC; the disease is pituitary gland adenoma.