The levels of ACTH did not vary (p = 0.37) in patient with and without distant metastases (median 75.64 pmol/l; IQR 58.30pmol/l vs 45.80 pmol/l; IQR 37.44pmol/l), although if outliers are omitted (1421pg/ml in one case of esthesioneuroblastoma without metastases), the differences become more apparent, though still not significant (75.64 pmol/l; IQR 58.30pmol/l vs 41.95 pmol/l; IQR 24.06 pmol/l in cases without metastases; p = 0.13). The gene discussed is POMC; the disease is olfactory neuroblastoma.