NOTCH1 and non-small cell lung carcinoma: To verify that GPER‐mediated NSCLC cell growth is dependent of NOTCH1, we conducted interruption assays and the data revealed that knock‐down of NOTCH1 (Figure S1D) could partially block GPER‐induced cell growth of H1299 cells, monitored by MTT (Figure 2G) and colony formation approach (Figure 2H).