To further verify that circNOTCH1 was indeed involved in GPER‐mediated cell growth of NSCLC, we performed interruption assays in H1299 cells, and the results displayed that knock‐down of circNOTCH1 could block GPER‐induced cell growth of H1299 cells, monitored by colony formation assay (Figure 3G) and MTT assay (Figure 3H). Here, GPER1 is linked to non-small cell lung carcinoma.