HIF1A and non-small cell lung carcinoma: To dissect the mechanism by which GPER altered NSCLC cell growth, we then examined the expression levels of some selective oncogenes related to cell growth/proliferation and found that knock‐down of GPER in A549 cells led to decreasing the expression levels of NOTCH1, Hif‐1α, β‐catenin, CXCR4, CENPE and C‐MYC at mRNA level (Figure 2A).