Our detection from qRT‐PCR demonstrated that the expression levels of has_circ_0089548 and has_circ_0089552 were consistently altered upon the manipulation of GPER in A549 and H1299 cells, indicating they may be involved in the process of GPER‐induced NOTCH1 in NSCLC cells (Figure 3A). This evidence concerns the gene GPER1 and non-small cell lung carcinoma.