Liver kinase B1 (LKB1) is a tumor suppressor, metabolic sensor, and master modulator of AMP-activated protein kinase (AMPK) and mammalian target of rapamycin complex1 (mTORC1) activity, leading to the control of energy metabolism, cell polarity, cell survival, and proliferation (Corradetti et al., 2004; Alessi et al., 2006; Nakada et al., 2010). The gene discussed is STK11; the disease is neoplasm.