We therefore hypothesized that increased bacterial infection by loss of intestinal epithelium barrier could contribute to the mouse death caused by co-deletions of Stk11 and Atg7. Hence, we treated the Stk11-/- and Atg7-/-;Stk11-/- mice with broad-spectrum antibiotics and assessed the mouse survival rate in comparison with untreated ones. The gene discussed is ATG7; the disease is bacterial infectious disease.