In line with declining HAV seroprotection, some studies have shown an increase in the proportion of acute viral hepatitis cases that are due to HAV over time.26,50 Hussain et al.26 studied 1932 patients with acute viral hepatitis at a tertiary care center in Northern India, of whom 11.4% overall were HAV-IgM positive (indicating current infection). The gene discussed is CD40LG; the disease is viral hepatitis.