Nanotechnology can aid in the development of fast, sensitive, and accurate methods for sepsis detection.[20, 21] Several NPs have been investigated to allow the diagnosis of sepsis‐related microbial infections, such as magnetic (MNPs), gold (AuNPs), fluorescent (silica and quantum dots QDs), and lipid‐based NPs.[22, 23, 24, 25, 26] Most of them are primarily used as contrast agents and biosensors to facilitate the detection of either proteins and nucleic acids associated with sepsis (CRP, PCT, and miRNA), pathogenic DNA or bacterial cells by amplifying signals. Here, CRP is linked to Sepsis.