For example, different CMT‐linked variants of GlyRS, HisRS and TyrRS lead to shared neomorphic structural opening which allows aberrant interactions with membrane receptors or intracellular proteins, thereby interfering with certain signaling pathways and trafficking in motor and sensory neurons (Blocquel et al., 2017, 2019; He et al., 2011, 2015). This evidence concerns the gene GARS1 and Charcot-Marie-Tooth disease.