Notably, overexpression of WT GlyRS could not improve the neuropathy phenotypes in either GarsNmf249/+ or GarsC201R/+ mice (Motley et al., 2011), and the same conclusion regarding another GARSG240R variant was reached with Drosophila CMT models, which showed no phenotypic rescue upon overexpression of the WT proteins (Niehues et al., 2015). Here, GARS1 is linked to Charcot-Marie-Tooth disease.