Among them, five genes (GARS, YARS, AARS, HARS and WARS) encode aminoacyl‐tRNA synthetases (aaRSs) including glycyl‐, tyrosyl‐, alanyl‐, histidyl‐ and tryptophanyl‐tRNA synthetases (GlyRS, TyrRS, AlaRS, HisRS and TrpRS, respectively) (Antonellis et al., 2003; Jordanova et al., 2006; Latour et al., 2010; Tsai et al., 2017; Vester et al., 2013), which is the largest family implicated in CMT and highlights the vital importance of aaRSs in the pathogenesis of CMT. This evidence concerns the gene GARS1 and Charcot-Marie-Tooth disease.