Moreover, silencing of MALAT1 drastically increased mRNA levels of pro-apoptotic factor Bim (a member of the Bcl-2 family) and induced pro-inflammatory cytokines, such as E-selectin, monocyte chemoattractant protein (MCP-1), and interleukin-6 (IL-6) after cerebral ischemia. Here, IL6 is linked to Cerebral ischemia.