They also observed significant interaction between TERT mutation and MGMT methylation.37 Pekmezci et al. analyzed 309 IDH-wildtype GBM case (including 77% TERT-mutant) and reported TERT mutation was not associated with OS, but they did not account for MGMT status.39 Therefore, our study is consistent with the majority of prior studies suggesting that TERT mutation is not an independent prognostic factor for IDH-wildtype GBM. The gene discussed is MGMT; the disease is glioblastoma.