The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) recently proposed a diagnostic entity of grade II-III IDH-wildtype astrocytoma that should behave similarly as histological GBM (hGBM): diffuse astrocytic glioma, IDH-wildtype with molecular features of glioblastoma, WHO grade IV (referred hereafter as molecular GBM). The gene discussed is IDH2; the disease is astrocytoma (excluding glioblastoma).