They also observed significant interaction between TERT mutation and MGMT methylation, in which the clinical outcomes of TERT-mutant versus TERT-wildtype differed depending on the MGMT methylation status.38 In contrast, Nguyen et al. analyzed 303 IDH-wildtype GBM (including 75% TERT-mutant) and did not observe significant association of TERT mutation with OS and PFS. This evidence concerns the gene IDH2 and glioblastoma.