GATA1 and erythroleukemia: Interestingly, DNA methylation by DNMT3A or the Tet methylcytosine dioxygenase (TET2) was shown to regulate hematopoietic differentiation by controlling accessible binding sites for hematopoietic transcription factors including GATA1.7 Moreover, very recent work has shown that precise DNA methylation patterning can control the binding and regulation of GATA1 activity.8 Collectively, these findings suggest that the erythroleukemia-like phenotype in Nsd1-/- mice is probably the consequence of altered crosstalk between histone and DNA methylation.