This process is conducted by multiple histone lysine methyltransferase (KMT) enzymes and results in either activation or repression of gene expression.1 Recurrent genetic alterations in KMT leading to aberrant histone modifications are frequently detected in acute myeloid leukemia (AML) and have been shown to act as drivers of the disease.2 Here, CAMKMT is linked to acute myeloid leukemia.