IL4 and helminthiasis: Interleukin-10, IL-4 and IL-13 are especially important to host tolerance of helminth infection because IL-10 is anti-inflammatory, while IL-4 and IL-13 are involved in the repair of tissue damage caused by STH migration through the skin (hookworm) and lungs (hookworm and ascarids), as well as damage to intestines when STHs feed directly (hookworm and whipworm) (Table 1) [8].