In this regard, Zhang et al. showed that the derived exosomes from human embryonic kidney (HEK) 293T cells, as carriers of hepatocyte growth factor (HGF) siRNA, could inhibit the HGF-c/MET pathway and prevent tumor growth and angiogenesis in gastric cancer; the decreased tumor size in their study is in agreement with the findings of our study (18). The gene discussed is HGF; the disease is gastric cancer.