Decreased renal fibrosis, inhibited apoptosisDecreased inflammation, increased renal toxicityDecreased macrophage infiltration, improved renal functionDecreased fibrosis, increased GFRInhibited renal interstitial apoptosis and fibrosisReinforced renal antioxidant system Increased RBF and decreased RVR, oxidative stress and macrophage infiltration parametersIncreased RVR and decreased RBFReduced angiotensin 1-7 biological effects, induced kidney injuryDecreased renal dysfunction and increased renal recoverabilityAttenuated kidney injuryIncreased RBF and GFR. The gene discussed is AGT; the disease is renal fibrosis.