So that the MSCs (reducing renal injury), L-arginine (attenuates the renal function), BMP-7 (inhibits the renal fibrosis), epidermal growth factor (inhibits the renal apoptosis and fibrosis), Losartan (accelerating the renal recovery), angiotensin receptor subtype 2, angiotensin (1-7) and Mas receptor (plays a renoprotective role), Enalapril, Aliskiren and other RAS antagonists (attenuates the renal injury) and Bosentan (reduce the endothelin-negative effects) have renoprotective effect in RUUO animal model. The gene discussed is AGT; the disease is renal fibrosis.