EZH2 and neoplasm: Our results are consistent with the studies of some other authors who detected that overexpression of EZH2 was associated with larger tumor size, advanced disease, and significantly worse disease free and overall survival than those with tumors expressing low EZH2, but added that overexpression of EZH2 was associated with negative ER status.15,16 Reijm et al. showed that high EZH2 expression was associated with the lymph node status only in univariate analysis.