Obese patients are usually accompanied by insulin resistance, so the basal insulin secretion value of these patients is higher than that of normal people.17 The fasting insulin value of patients in this group before weight loss is of 26.96 ± 1.98 uu/ml (normal reference value of RIA method is of 5 - 20 uu/ml). The gene discussed is INS; the disease is Insulin resistance.