Assessment of hormonal variations in a sample of Pakistani women suffering from polycystic ovary syndrome revealed elevated body mass index, Luteinizing Hormone (LH), insulin, prolactin, androstenedione and testosterone which are also responsible for sexual desire and performance.4,5 Though, the link of gynaecological issues such as PCOS with sexual dysfunction is often bidirectional, it is difficult to ascertain which had appeared first.6 Elevated androgen levels due to PCOS bring changes in body that effects sexual functioning. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.