The most common chromosomal rearrangement in lipomas involves fusions of HMGA2; while, chimeric genes derived from the fusion of HMGA2 with multiple different partners were suggested to play a role in lipomatous development [8, 9], the same gene fusions have been identified in other benign mesenchymal tumors, such as chondromas, with no lipid accumulation [10–12]. This evidence concerns the gene HMGA2 and benign mesenchymoma.