KLB and hepatocellular carcinoma: High and intermediate levels of FGFR-4 were detected in 39.7% (25/63) and 38.1% (24/63) of HCC models, respectively, while high and intermediate levels of Klotho-β were observed in 19.0% (12/63) and 34.9% (22/63) of HCC PDXs, respectively.