Additionally, the signalling pathway was centered around Akt1, which was connected to PTGS2, IL-6, JUN, VEGFA, EGFR, ERK2 MAPK1, JNK1 MAPK8, c-Fos and CASP3, as important targets of BXHP for treating SD. The gene discussed is MAPK1; the disease is Salla disease.