By provoking ER and mitochondrial stress as well as increased intracellular calcium levels, insulin resistance and ensuing hyperglycemia may enhance the probality of self- and cross-seeding of αSyn and IAPP in β-cells by increasing the levels, and thus availability, of endogenous, unfolded and misfolded IAPP and αSyn. The gene discussed is IAPP; the disease is Hyperglycemia.