IAPP and type 2 diabetes mellitus: Electron microscopy (TEM) analyses of double αSyn and IAPP immunogold labelled islets isolated from hIAPPtg mice and T2D individuals showed that, as previously described using the proximity-ligation-assay on human pancreatic sections11, αSyn and IAPP co-exists in close proximity in β-cells (Supplementary Fig. 1a-h).