In contrast, in NAFLD patients and obese mice, binding of SHP and DNMT3A at the lipogenic genes and DNA methylation is decreased, suggesting that a dysregulated FGF15/19-SHP-DNMT3A axis contributes to the elevated lipogenesis that has been observed in obesity3,4 (Model, Fig. 9e). This evidence concerns the gene DNMT3A and metabolic dysfunction-associated steatotic liver disease.