Further, adipo-specific DNMT3A-KO mice were protected from diet-induced insulin resistance and glucose intolerance, adipocyte Fgf21 was identified as a target gene inhibited by DNMT3A, and intriguingly, DNA methylation at the Fgf21 gene was elevated in adipose tissue of diabetic patients29. The gene discussed is FGF21; the disease is Glucose intolerance.