Compared with patients without ACI, patients who developed ACI were older, had more comorbidities (e.g. hypertension, DM, CHD, and COPD), lower readings of the lymphocyte count, eGFR and OOS, but higher readings of the leukocyte count, ALT, IL-6, hs-CRP, and NT-proBNP on admission (all P < 0.05) (Table 2). The gene discussed is IL6; the disease is hypertensive disorder.