Hs-cTnI has been suggested as a primary indicator for determining cardiac injury, which represents the degree of myocardial injury(ACI)15,16, and the occurrence of ACI has been confirmed to be associated with extremely high in-hospital mortality in COVID-19 patients6,9,17–20, so the definition of ACI is critical to the prognosis of COVID-19 patients21–23. Here, TNNI3 is linked to COVID-19.