SETD1A and psychiatric disorder: Assuming an odds ratio of 10, which is still less than the known major genetic risk factors of psychiatric disorders such as 22q11.2 deletion for schizophrenia (odds ratio = 67.7)25 and loss of function mutations of SETD1A (Odds ratio = 20.0 calculated from SCHEMA browser) and given the statistical power to detect the association is 0.79, it may be possible to determine association of the SNP in a reasonably sized case–control study.