Genetic interaction of DRD2-ADORA2A variants has been shown to affect caffeine-induced anxiety26, whereas DRD2 variants alone, notably the DRD2/ANKK1 variant rs1800497 (Taq1A polymorphism), were reported to be associated with anxiety symptoms/disorders (e.g.,38–41). The gene discussed is ADORA2A; the disease is Anxiety.