Insulin resistance and beta cell dysfunction are the most prominent metabolic features of type 2 diabetes.[9] Moreover, early initiation of insulin, alone or in combination with metformin, has been shown to improve glycemic control and preserve pancreatic β-beta cell function in patients with DM.[15,17] In the present study, no significant effect on glycemic control was observed among patients receiving insulin alone or in combination with metformin. Here, INS is linked to Insulin resistance.