Pathological finding revealed the histologic pattern of tumor was glandular, and some of the glands contained luminal eosinophilic material (Fig. 1), and the immunohistochemical results in our institution showed positive staining for PAX8 (paired box gene 8), CD10, GATA3 (GATA binding protein 3) and TTF-1 (thyroid transcription factor 1) (Fig. 2A–D), while negative staining for ER (estrogen receptor), PR (progesterone receptors), P53, and P16 (Fig. 2E–H). The gene discussed is ESR1; the disease is neoplasm.