Our previous research has revealed that YQHYJD decoction can suppress the invasion and metastasis of GC cells, the mechanism of which may be related to TGF-β/Smad pathway.[7] The present project takes YQHYJD decoction or placebo combined with chemotherapy, to evaluate the efficacy of this prescription in the treatment of GC metastasis and recurrence, so as to form a treatment scheme suitable for clinical promotion and provide a higher level of evidence-based medical basis for TCM in the prevention and treatment of postoperative recurrence and metastasis in GC. The gene discussed is TGFB1; the disease is gastric cancer.