Empirical evidence demonstrated that liver damage is an important risk factor for severe outcome and death in SARS and MERS.[28,29] Previous studies indicated SARS-CoV-2 can enter the host cells by binding to the angiotensin-converting enzyme 2 (ACE2) receptor.[30] Thus, it is urgent to investigate whether existing liver diseases and other digestive comorbidities are associated with COVID-19 prognosis. This evidence concerns the gene ACE2 and COVID-19.