PKM and obesity due to melanocortin 4 receptor deficiency: For instance, expression of the glycolytic enzyme PKM2 is positively associated with obesity in EAC patients [30], overexpression of uncoupling protein-2 (UCP2) abrogated cigarette smoking condensate and deoxycholic acid mediated increases in lactate and ATP production in EAC; these links may provide novel strategies for EAC therapy [31].