MAPT and Alzheimer disease: At the same time, Tau protein phosphorylation levels were significantly increased in AD mice, with no remarkable effect on the protein expression of Tau (Figure 7C), accompanied by clearly increased levels of ROS (Figure 7D) and MDA (Figure 7E) as well as LDH activity (Figure 7F), but obviously lower levels of SOD and GSH-Px (Figure 7F).