The development of cardiomyopathy and skeletal myopathy associated with subsarcolemmal myosin accumulation and non-ubiquinated aggregates of fragmented sarcomeres were observed in a patient with compound MuRF1 (TRIM63) deficiency and a deleterious MuRF3 (TRIM54) missense mutation (Olive et al., 2015). Here, TRIM63 is linked to cardiomyopathy.