Biochemical and biophysical characterization of the effects of the myosin storage myopathy mutations in the LMM region have suggested adverse effects of the mutations in the ability of the protein to form stable and functional thick filaments (Armel and Leinwand, 2009), and that each mutation has a unique effect on the ability to form accumulated materials (Dahl-Halvarsson et al., 2017). Here, MYH14 is linked to myopathy.